Counter the Adverse Health Effects of Pollution
By Michael Downey
According to researchers from the Massachusetts Institute of Technology, air pollution is responsible for as many as 200,000 premature deaths every year in the US alone.1
Air pollution has become a serious global health epidemic. About 80% of people live in areas of the world where air pollution exceeds the World Health Organization’s air-quality guidelines.2 This exposure is associated with higher rates of cardiovascular and respiratory illnesses and death.3,4
New studies link pollution to glucose intolerance,5 along with asthmatic mothers delivering preterm babies,6 and damage to blood vessels in individuals as young as 23!7
While we can’t avoid all air pollution, we can help protect ourselves from its damaging effects. Researchers have identified specific nutrients that can inhibit some of the effects of pollutants—and even help remove them from the body.
We are barraged with toxic compounds from industrial facilities, agricultural runoff, chemicals used on military bases, pesticide-laced foods, and emissions from trucks, cars, and planes.
Over 80,000 chemicals have been synthesized over the last 70 years—many of which are known carcinogens—and more than 4 billion pounds of these chemicals are released into the environment every year.8-11 The vast majority have never been adequately tested by the Environmental Protection Agency (EPA) or any other government agency to evaluate their human health effects.12
In 2009, the Centers for Disease Control and Prevention (CDC) investigated the burden of 212 industrial chemicals in US citizens’ bodies and found high levels of many common industrial chemicals, including polybrominated diphenyl ethers (PBDEs) and bisphenol A (BPA),13 a chemical known for negatively affecting reproduction.14
Perfluoroalkyl chemicals have been found to be present in more than 98% of people sampled,15 and one member of this chemical family—perfluorooctanoic acid (PFOA), best known for being part of the substance TeflonTM—is linked with diseases ranging from kidney disease to cancer.16-19
Among the most commonly studied air pollutants are fine particulates, which are high-risk particles often measured as PM2.5 (indicating particles less than 2.5 microns in diameter). But even larger particles known as PM10 can travel deep into the body—through the bronchioles of the lung to the alveoli and even into the bloodstream, seriously damaging critical body functions.20-22 (For perspective, a human hair is about 70 microns in diameter.20)
Chronic exposure to pollution is linked to some of the most insidious diseases of our time. These include:
Cardiovascular and respiratory diseases,3,4,7,20-22
Premature births (among asthmatic mothers),6
Increased mortality30 and reduced life expectancy.31-33
How Pollution Damages Human Tissues
Scientists have found three main ways in which pollutants negatively impact our bodies.
First, fine particulates alter the autonomic nervous system,21,34 which is part of the peripheral nervous system and a regulator of cardiac function, among other functions. The resulting nervous system dysfunction leads to an abnormal decrease in heart rate variability. This means there is less variation in the time intervals between heartbeats, a condition that is associated with increased cardiac mortality.34
Second, environmental pollutants cause the overproduction of reactive oxygen and nitrogen species.35-37 When we inhale these tiny particles, they reduce antioxidant defenses in our respiratory tract, including glutathione and superoxide dismutase.38 If we don’t have enough of these protective substances, production of reactive oxygen species (ROS) is increased and oxidants can damage organic molecules. And of course, the damage caused by oxidative stress to cellular components contributes to a range of chronic diseases from cancer to aging.35
Air pollution also increases body-wide inflammation.5,39 Evidence shows that rising pollution corresponds to increased blood levels of cytokines, which are chemical messengers.7
Fortunately, researchers have identified several nutrients that are capable of interfering with these pollution pathways. This means that even though we can’t avoid exposure to ubiquitous environmental toxins, taking the proper nutrients can reduce our susceptibility to their damaging effects.
Let’s examine these nutrients individually.
What You Need to Know
Block the Devastating Effects of Pollution
Globally, most people live in areas where air pollution exceeds World Health Organization air-quality guidelines.
Chronic exposure to pollution boosts the risk of cardiovascular and respiratory morbidity and death, glucose intolerance, preterm deliveries, and endothelium damage.
Certain remarkable nutrients have the capacity to block the destructive effects of pollution and, in some instances, even remove pollutants from the body.
While it is impossible to avoid pollution, we can protect ourselves by supplementing with these protective nutrients.
Omega-3 Fatty Acids
One of the most damaging effects of pollution is its ability to increase oxidative stress in the body.35-37 Omega-3 fatty acids are able to help combat harmful oxidative stress by increasing the body’s protective defense systems.
Scientists studied an elderly population to determine if supplemental omega-3 polyunsaturated fatty acid (PUFA) from fish oil would have an impact on the oxidative response induced by exposure to PM2.5 pollution particles.40 They found that taking just 2 grams of fish oil daily for four months helped protect the body against oxidative stress. Specifically, it led to a 49% increase in superoxide dismutase (SOD) activity, a 62% increase in glutathione (GSH), and a 72% decrease in lipoperoxidation—all indicative of higher activity of endogenous antioxidants.40
In another study, healthy, middle-aged individuals took 3 grams of omega-3s from fish oil daily for three weeks and were then exposed to concentrated ambient fine and ultrafine particles. The researchers found that the omega-3s blocked the harmful cardiac and lipid effects induced by the particulate matter.41
Research shows that consuming adequate amounts of certain B vitamins can help prevent a potentially deadly impact of pollution: a decrease in heart rate variability.42
Researchers found that individuals with a lower dietary intake of folate, vitamin B6, and vitamin B12 showed significantly decreased heart rate variability 48 hours after an increase in ambient PM2.5 levels.42
However, in those with a high, daily dietary intake of these nutrients, negative effects of increased particulate pollution were prevented.42
Vitamins C and E
Vitamins C and E have been found to work together to help protect the body against oxidative stress caused by air pollution.
Researchers measured oxidative stress biomarkers in individuals exposed to coal-burning emissions from an electric-power plant before and after supplementation with 500 mg of vitamin C and 800 mg of vitamin E, which were then compared to nonexposed individuals (control). After six months, they again measured these biomarkers.43
Prior to supplementation, the individuals that were exposed to the polluted air experienced numerous breaches in their bodies’ defense systems. For example, they had decreased levels of some protective substances (including glutathione and vitamin E), and the activities of several antioxidant enzymes were impaired (including catalase, glutathione peroxidase, glutathione reductase, and glutathione s-transferase). In addition, markers for lipid and protein damage increased.43
After supplementing with vitamins C and E, markers for lipid and protein damage were decreased and antioxidant defenses were significantly improved to levels seen in the control group that was not exposed to pollution—indicating protection against air pollution-induced oxidative stress in the body.43
Some trials have also shown the benefits of using vitamins C and E in combination on asthma patients to help reduce ozone-associated lung-function decline44 and ozone-induced bronchial hyperresponsiveness.45
Air pollution has a direct negative influence on vitamin D status because it interferes with the amount of ultraviolet-B (UVB) radiation that reaches ground level and human skin.
One study found that to attain the same blood levels of vitamin D from sun exposure as rural residents—as measured by 25-hydroxyvitamin D [25(OH)D] serum levels—residents of polluted urban areas would need two to three times the “sun exposure index.”46
In another study, children living in an area of Delhi affected by high levels of air pollution were shown to have mean serum 25(OH)D levels that were 54% lower than those in children living in less polluted areas of the same city.47 Similarly, women living in the polluted Iranian city of Tehran were shown to have lower vitamin D levels than women living in Ghazvinian, a less-polluted city in Iran.48
Since any amount of sun exposure damages skin DNA, it’s better to obtain vitamin D in low-cost supplement form.
Studies have found that both broccoli extract and the broccoli compound sulforaphane work in numerous ways to protect the body against the harmful effects of air pollution.
Breathing in polluted air can be especially damaging to the respiratory system, leading to oxidative stress that can set the stage for asthma and other airway diseases. One important study found that sulforaphane can induce the gene expression of enzymes that help combat oxidative stress in the upper airway.49 As a result, the researchers concluded that sulforaphane could be a “novel therapeutic strategy” for oxidant-induced airway disease. Along those same lines, broccoli sprout extracts containing a sulforaphane precursor have also been found to reduce the nasal allergic response to diesel exhaust particles.50
Broccoli sprouts have also been found to rapidly—and sustainably—detox the body of airborne pollutants. It works by promoting the rapid excretion from the body of carcinogenic air pollutants (including benzene).51 This is especially important since exposure to air pollution has been linked to lung cancer and cardiopulmonary diseases.
A component in Brussels sprouts, called glucosinolates, can reduce the oxidative DNA damage caused by environmental toxins by up to 28%.52 They reduce the carcinogenicity of many environmental toxins by boosting the genetic expression of important detoxifying enzymes.53,54
Finally, watercress, a lesser-known cruciferous vegetable, contains a derivative of glucosinolate that has been found to protect against DNA damage,55,56 making watercress extract protective against high-risk environmental carcinogens, such as those found in tobacco smoke.57-59
Research conducted by the United States Environmental Protection Agency demonstrated that olive oil consumption prevented reduction in blood vessel dilation due to pollution.60
For the study, scientists gave 42 subjects 3 grams of either olive oil or fish oil every day for one month, and a third group served as controls. Participants were then exposed to two hours of filtered air to determine a baseline, and the next day they were exposed to two hours of fine and ultrafine concentrated ambient particulate matter (a dangerous component of air pollution). Next, the researchers tested the subjects’ endothelial function by measuring their flow-mediated dilation of the brachial artery and their fibrinolysis, the body’s natural anti-clotting mechanism.
They found that flow-mediated dilation was reduced in the control group and, to a lesser extent, in the fish oil group as well. However, the olive oil group showed no statistically significant reduction in dilation, which means they were protected against the effects of the polluted air on their blood vessels’ ability to dilate.60
As an added benefit, beginning immediately after exposure to the polluted air and continuing for a full 20 hours, the olive oil group experienced elevated levels of plasminogen activator, a protein that breaks down clots. Olive oil also improved markers associated with both vasoconstriction of blood vessels and fibrinolysis.60
Based on fish oil’s beneficial properties that protect against the effects of pollution, it makes sense to include fish and olive oils in your diet and/or supplement program.
Chlorophyllin delivers special protection against pollution through its novel ability to bind to toxins and excrete them from the body before they can induce mutations in DNA and trigger cancer.61-63
For example, one extremely dangerous environmental pollutant is DBP (dibenzo[a,l]pyrene), found in coal tar and cigarette smoke. It is one of the most potent environmental carcinogens known.64 In a fish study, scientists found that chlorophyllin was able to reduce the amount of DBP in the liver by up to 63%.65
The Premature Death Toll from an Isolated Jump in Pollution
Underscoring the health risks of global air pollution is the increased mortality that can arise from an isolated source of pollution—as shown by the numbers in the Volkswagen emissions-cheat case.
In September 2015, the US Environmental Protection Agency discovered that the German automaker had developed and installed “defeat software” in 11 million of its diesel vehicles sold between 2008 and 2015. This software sensed when a car was undergoing an emissions test and would only then engage the vehicle’s full emissions-control system, which would otherwise be disabled. This cheat allowed vehicles to emit 10-40 times more emissions than legally permitted under the Clean Air Act.66
Multiplying that amount of excess pollution by the 2.6 million such vehicles sold in Germany alone—and extrapolating over the population of Europe—scientists at the Massachusetts Institute of Technology estimate that 1,200 Europeans will die prematurely as a result of this single pollution source, with 500 of them losing as much as a decade of life. Premature deaths will occur as far away from the German vehicles as the Czech Republic and Poland.67
The MIT scientists also predicted that if Volkswagen could somehow recall and fix all of the remaining cars to meet emissions limits by the end of 2017, it could save an additional 2,600 premature deaths across Europe.67
In the US, where far fewer of these vehicles were sold, deaths attributed to the emissions “cheat software” are still estimated to reach about 106.68
But the death toll estimates don’t include the nonfatal health effects that are spread over a much larger number of individuals. The nitrogen dioxide and ozone from tail pipes increase airway inflammation, asthma, bronchitis, wheezing, heart attacks, and chronic obstructive pulmonary disease, with older people at greater vulnerability.69
Even if it cannot be measured, air pollution affects the health of everyone to at least some extent.
A spokesman for Volkswagen pointed out that the firm’s current vehicles pump out dangerous pollutants at levels that are “comparable” to those of their competitors.67 In light of the four billion euros in additional health costs, the unnecessary years of ill health—and the early deaths of thousands of people—that just doesn’t seem very comforting.
Most people are chronically exposed to air pollution that exceeds WHO air-quality standards. Over time, this causes changes in the body that can lead to cardiovascular and respiratory disease, increased glucose intolerance, increased risk of preterm deliveries, and endothelium damage.
Scientists have identified certain nutrients that can inhibit the harmful effects of pollutants and even help remove them from the body.
This means that even though it is impossible to avoid environmental pollution, we can still protect ourselves from its harmful effects.
If you have any questions on the scientific content of this article, please call a Life Extension® Wellness Specialist at 1-866-864-3027.
Caiazzo F, Ashok A, Waitz IA, et al. Air pollution and early deaths in the United States. Part I: Quantifying the impact of major sectors in 2005. Atmospheric Environment. 2013;79:198-208.
van Donkelaar A, Martin RV, Brauer M, et al. Global estimates of ambient fine particulate matter concentrations from satellite-based aerosol optical depth: development and application. Environ Health Perspect. 2010;118(6):847-55.
Brook RD. Cardiovascular effects of air pollution. Clin Sci (Lond). 2008;115(6):175-87.
Peters A. Particulate matter and heart disease: evidence from epidemiological studies. Toxicol Appl Pharmacol. 2005;207(2 Suppl):477-82.
Wolf K, Popp A, Schneider A, et al. Association Between Long-term Exposure to Air Pollution and Biomarkers Related to Insulin Resistance, Subclinical Inflammation, and Adipokines. Diabetes. 2016;65(11):3314-26.
Mendola P, Wallace M, Hwang BS, et al. Preterm birth and air pollution: Critical windows of exposure for women with asthma. J Allergy Clin Immunol. 2016;138(2):432-40.e5.
Pope CA, 3rd, Bhatnagar A, McCracken JP, et al. Exposure to Fine Particulate Air Pollution Is Associated With Endothelial Injury and Systemic Inflammation. Circ Res. 2016;119(11):1204-14.
Lloyd-Smith M, Sheffield-Brotherton B. Children’s environmental health: intergenerational equity in action--a civil society perspective. Ann N Y Acad Sci. 2008;1140:190-200.
Available at: https://archive.epa.gov/epapages/newsroom_archive/newsreleases/c36c6bee520812d585257af5007b9e98.html. Accessed February 24, 2017.
Crews D, Gore AC. Epigenetic synthesis: a need for a new paradigm for evolution in a contaminated world. F1000 Biol Rep. 2012;4:18.
Available at: http://www.worldometers.info/view/toxchem/. Accessed February 27, 2017.
Thornton JW, McCally M, Houlihan J. Biomonitoring of industrial pollutants: health and policy implications of the chemical body burden. Public Health Rep. 2002;117(4):315-23.
Available at: https://www.cdc.gov/exposurereport/. Accessed February 24, 2017.
Available at: https://www.cdc.gov/biomonitoring/BisphenolA_FactSheet.html. Accessed February 24, 2017.
Calafat AM, Wong LY, Kuklenyik Z, et al. Polyfluoroalkyl chemicals in the U.S. population: data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and comparisons with NHANES 1999-2000. Environ Health Perspect. 2007;115(11):1596-602.
Steenland K, Zhao L, Winquist A, et al. Ulcerative colitis and perfluorooctanoic acid (PFOA) in a highly exposed population of community residents and workers in the mid-Ohio valley. Environ Health Perspect. 2013;121(8):900-5.
Watkins DJ, Josson J, Elston B, et al. Exposure to perfluoroalkyl acids and markers of kidney function among children and adolescents living near a chemical plant. Environ Health Perspect. 2013;121(5):625-30.
Lopez-Espinosa MJ, Mondal D, Armstrong B, et al. Thyroid function and perfluoroalkyl acids in children living near a chemical plant. Environ Health Perspect. 2012;120(7):1036-41.
Barry V, Winquist A, Steenland K. Perfluorooctanoic acid (PFOA) exposures and incident cancers among adults living near a chemical plant. Environ Health Perspect. 2013;121(11-12):1313-8.
Available at: https://www.epa.gov/pm-pollution/particulate-matter-pm-basics#PM. Accessed February 24, 2017.
Brook RD, Rajagopalan S, Pope CA, 3rd, et al. Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation. 2010;121(21):2331-78.
Miller MR. The role of oxidative stress in the cardiovascular actions of particulate air pollution. Biochem Soc Trans. 2014;42(4):1006-11.
Park SK, O’Neill MS, Wright RO, et al. HFE genotype, particulate air pollution, and heart rate variability: a gene-environment interaction. Circulation. 2006;114(25):2798-805.
Oftedal B, Brunekreef B, Nystad W, et al. Residential outdoor air pollution and lung function in schoolchildren. Epidemiology. 2008;19(1):129-37.
Rojas-Martinez R, Perez-Padilla R, Olaiz-Fernandez G, et al. Lung function growth in children with long-term exposure to air pollutants in Mexico City. Am J Respir Crit Care Med. 2007;176(4):377-84.
Pope CA, 3rd, Burnett RT, Thun MJ, et al. Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. Jama. 2002;287(9):1132-41.
Raaschou-Nielsen O, Andersen ZJ, Beelen R, et al. Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE). Lancet Oncol. 2013;14(9):813-22.
Ranft U, Schikowski T, Sugiri D, et al. Long-term exposure to traffic-related particulate matter impairs cognitive function in the elderly. Environ Res. 2009;109(8):1004-11.
Available at: http://www.erswhitebook.org/Chapters/Outdoor-Environment/. Accessed February 27, 2017.
Hoek G, Brunekreef B, Goldbohm S, et al. Association between mortality and indicators of traffic-related air pollution in the Netherlands: a cohort study. Lancet. 2002;360(9341):1203-9.
Pope CA, 3rd, Ezzati M, Dockery DW. Fine-particulate air pollution and life expectancy in the United States. N Engl J Med. 2009;360(4):376-86.
Chen Y, Ebenstein A, Greenstone M, et al. Evidence on the impact of sustained exposure to air pollution on life expectancy from China’s Huai River policy. Proc Natl Acad Sci U S A. 2013;110(32):12936-41.
Correia AW, Pope CA, 3rd, Dockery DW, et al. Effect of air pollution control on life expectancy in the United States: an analysis of 545 U.S. counties for the period from 2000 to 2007. Epidemiology. 2013;24(1):23-31.
Holguin F, Tellez-Rojo MM, Hernandez M, et al. Air pollution and heart rate variability among the elderly in Mexico City. Epidemiology. 2003;14(5):521-7.
Poljsak B, Fink R. The protective role of antioxidants in the defence against ROS/RNS-mediated environmental pollution. Oxid Med Cell Longev. 2014;2014:671539.
Nel AE, Diaz-Sanchez D, Li N. The role of particulate pollutants in pulmonary inflammation and asthma: evidence for the involvement of organic chemicals and oxidative stress. Curr Opin Pulm Med. 2001;7(1):20-6.
Fujisawa T. Role of oxygen radicals on bronchial asthma. Curr Drug Targets Inflamm Allergy. 2005;4(4):505-9.
Kelly FJ, Mudway IS. Protein oxidation at the air-lung interface. Amino Acids. 2003;25(3-4):375-96.
Zeka A, Sullivan JR, Vokonas PS, et al. Inflammatory markers and particulate air pollution: characterizing the pathway to disease. Int J Epidemiol. 2006;35(5):1347-54.
Romieu I, Garcia-Esteban R, Sunyer J, et al. The effect of supplementation with omega-3 polyunsaturated fatty acids on markers of oxidative stress in elderly exposed to PM(2.5). Environ Health Perspect. 2008;116(9):1237-42.
Tong H, Rappold AG, Diaz-Sanchez D, et al. Omega-3 fatty acid supplementation appears to attenuate particulate air pollution-induced cardiac effects and lipid changes in healthy middle-aged adults. Environ Health Perspect. 2012;120(7):952-7.
Baccarelli A, Cassano PA, Litonjua A, et al. Cardiac autonomic dysfunction: effects from particulate air pollution and protection by dietary methyl nutrients and metabolic polymorphisms. Circulation. 2008;117(14):1802-9.
Possamai FP, Junior SA, Parisotto EB, et al. Antioxidant intervention compensates oxidative stress in blood of subjects exposed to emissions from a coal electric-power plant in South Brazil. Environ Toxicol Pharmacol. 2010;30(2):175-80.
Romieu I, Sienra-Monge JJ, Ramirez-Aguilar M, et al. Antioxidant supplementation and lung functions among children with asthma exposed to high levels of air pollutants. Am J Respir Crit Care Med. 2002;166(5):703-9.
Trenga CA, Koenig JQ, Williams PV. Dietary antioxidants and ozone-induced bronchial hyperresponsiveness in adults with asthma. Arch Environ Health. 2001;56(3):242-9.
Manicourt DH, Devogelaer JP. Urban tropospheric ozone increases the prevalence of vitamin D deficiency among Belgian postmenopausal women with outdoor activities during summer. J Clin Endocrinol Metab. 2008;93(10):3893-9.
Agarwal KS, Mughal MZ, Upadhyay P, et al. The impact of atmospheric pollution on vitamin D status of infants and toddlers in Delhi, India. Arch Dis Child. 2002;87(2):111-3.
Hosseinpanah F, Pour SH, Heibatollahi M, et al. The effects of air pollution on vitamin D status in healthy women: a cross sectional study. BMC Public Health. 2010;10:519.
Riedl MA, Saxon A, Diaz-Sanchez D. Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway. Clin Immunol. 2009;130(3):244-51.
Heber D, Li Z, Garcia-Lloret M, et al. Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles. Food Funct. 2014;5(1):35-41.
Egner PA, Chen JG, Zarth AT, et al. Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. Cancer Prev Res (Phila). 2014;7(8):813-23.
Verhagen H, Poulsen HE, Loft S, et al. Reduction of oxidative DNA-damage in humans by brussels sprouts. Carcinogenesis. 1995;16(4):969-70.
James D, Devaraj S, Bellur P, et al. Novel concepts of broccoli sulforaphanes and disease: induction of phase II antioxidant and detoxification enzymes by enhanced-glucoraphanin broccoli. Nutr Rev. 2012;70(11):654-65.
Nijhoff WA, Grubben MJ, Nagengast FM, et al. Effects of consumption of Brussels sprouts on intestinal and lymphocytic glutathione S-transferases in humans. Carcinogenesis. 1995;16(9):2125-8.
Rose P, Faulkner K, Williamson G, et al. 7-Methylsulfinylheptyl and 8-methylsulfinyloctyl isothiocyanates from watercress are potent inducers of phase II enzymes. Carcinogenesis. 2000;21(11):1983-8.
Gill CI, Haldar S, Boyd LA, et al. Watercress supplementation in diet reduces lymphocyte DNA damage and alters blood antioxidant status in healthy adults. Am J Clin Nutr. 2007;85(2):504-10.
Hecht SS, Chung FL, Richie JP, Jr., et al. Effects of watercress consumption on metabolism of a tobacco-specific lung carcinogen in smokers. Cancer Epidemiol Biomarkers Prev. 1995;4(8):877-84.
Hecht SS. Approaches to chemoprevention of lung cancer based on carcinogens in tobacco smoke. Environ Health Perspect. 1997;105 Suppl 4:955-63.
Chung FL, Morse MA, Eklind KI, et al. Inhibition of tobacco-specific nitrosamine-induced lung tumorigenesis by compounds derived from cruciferous vegetables and green tea. Ann N Y Acad Sci. 1993;686:186-201; discussion -2.
Tong H, Rappold AG, Caughey M, et al. Dietary Supplementation with Olive Oil or Fish Oil and Vascular Effects of Concentrated Ambient Particulate Matter Exposure in Human Volunteers. Environ Health Perspect. 2015;123(11):1173-9.
Egner PA, Munoz A, Kensler TW. Chemoprevention with chlorophyllin in individuals exposed to dietary aflatoxin. Mutat Res. 2003;523-524:209-16.
Tachino N, Guo D, Dashwood WM, et al. Mechanisms of the in vitro antimutagenic action of chlorophyllin against benzo[a]pyrene: studies of enzyme inhibition, molecular complex formation and degradation of the ultimate carcinogen. Mutat Res. 1994;308(2):191-203.
Dashwood R, Yamane S, Larsen R. Study of the forces of stabilizing complexes between chlorophylls and heterocyclic amine mutagens. Environ Mol Mutagen. 1996;27(3):211-8.
Available at: https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+4029. Accessed February 27, 2017.
Simonich MT, McQuistan T, Jubert C, et al. Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout. Food Chem Toxicol. 2008;46(3):1014-24.
Available at: https://www.theguardian.com/business/2015/sep/22/vw-scandal-caused-nearly-1m-tonnes-of-extra-pollution-analysis-shows. Accessed March 12, 2017.
Available at: https://www.nytimes.com/2017/03/06/science/volkswagen-emissions-scandal-air-pollution-deaths.html. March 12, 2017.
Available at: https://www.nytimes.com/2015/09/29/upshot/how-many-deaths-did-volkswagens-deception-cause-in-us.html?_r=0. March 12, 2017.
Available at: http://grist.org/climate-energy/volkswagen-emissions-cheating-caused-100-million-in-health-costs-according-to-analysis/. March 12, 2017.
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